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. 2011 Jul 7;7(7):e1002089. doi: 10.1371/journal.pcbi.1002089

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This is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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A) We repeated the experiments carried out in Figure 3 to determine the optimal shape for eliciting an action potential with PSCs having either a long (20 msec) decay constant (green curve) or short (1 msec) decay constant (blue curve). These signals are particularly different 5 to 10 msec prior to the action potential. During this region, short PSCs excite the neuron, whereas long PSCs inhibit the neuron. B) Correlation analysis of the short versus long PSC results as described in the text. C) The intracellular pH of the axon was elevated to increase axon excitability (15) and the experiments in A were repeated. For the axon with enhanced excitability, the difference between the optimal signals comprised of short PSCs and those comprised of long PSCs was more pronounced.