On the left, a digital photograph of a hot oil burn to the hand with areas of deep (white) and partial (pink) thickness. On the right, the laser speckle image (LSI) of the same burn. Areas of high perfusion are represented by brighter colors (red, yellow, green, in order of decreasing perfusion) and lower perfusion is represented by blue. Deep thickness regions on the proximal second, third, and fourth digits correspond to light blue areas on the speckle image, whereas the dorsum of the hand overlying the metacarpals is partial thickness on clinical exam green/yellow/red on the speckle image. Uninjured, non-inflamed skin is blue. (Patient permission was obtained to publish photograph.) (For interpretation of the references to color in this figure legend, the reader is referred to the web version of the article.)