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. Author manuscript; available in PMC: 2011 Nov 1.
Published in final edited form as: Anticancer Agents Med Chem. 2011 May 1;11(4):341–346. doi: 10.2174/187152011795677544

Figure 9. MnSOD in the mitochondrial matrix is at the bifurcation point between 1-electron and 2-electron signaling.

Figure 9

The different signaling cascades provide a feedback mechanism for the high-flux metabolic circuit as well as low flux circuits that lead to gene expression, such as with the HIF pathway as presented in Fig. (2).