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. Author manuscript; available in PMC: 2012 Jul 1.
Published in final edited form as: Cancer Prev Res (Phila). 2011 Apr 13;4(7):1084–1094. doi: 10.1158/1940-6207.CAPR-10-0340

Figure 6.

Figure 6

GA suppresses STAT3-regulated proliferative, survival, and angiogenic gene products. U266 cells (2 × 106/mL) were treated with 2.5 µM GA for the indicated time intervals, after which whole cell extracts were prepared and 40 µg proteins resolved on 10% SDS-PAGE and probed against (A) c-IAP, survivin, Mcl-1, bcl-2, bcl-xl (B) cyclin D1, VEGF, COX-2, and ICAM-1 antibody. The same blots were stripped and reprobed with β-actin antibody to verify equal protein loading. (C) Schematic representation of mechanism by which GA inhibits STAT3 activation and induces apoptosis.