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. Author manuscript; available in PMC: 2012 Aug 1.
Published in final edited form as: Alcohol Clin Exp Res. 2011 Apr 4;35(8):1509–1518. doi: 10.1111/j.1530-0277.2011.01487.x

Figure 3. Alcohol-induced steatohepatistis through TLR4 on BM-derived cells and endogenous liver cells.

Figure 3

(A-D) The TLR4 chimeric mice [(a) WT mice with WT BM (n=9); (b) TLR4-/- mice with WT BM (n=6); (c) WT mice with TLR4-/- BM (n=7); (d) TLR4-/- mice with TLR4-/- BM (n=6)] were treated with intragastric feeding of alcohol for 4 weeks. Pathological changes were scored as described in Materials and Methods. (A) necrosis, (B) steatosis, (C) inflammation, and (D) total score are shown. Values with different letters are significantly different, p<0.05.