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. Author manuscript; available in PMC: 2012 Aug 1.
Published in final edited form as: Alcohol Clin Exp Res. 2011 Apr 4;35(8):1509–1518. doi: 10.1111/j.1530-0277.2011.01487.x

Figure 4. TLR4 on either BM-derived cells or endogenous liver cells participates in liver inflammation in mice fed ethanol diet.

Figure 4

(A-D) The TLR4 chimeric mice [(a) WT mice with WT BM (n=9); (b) TLR4-/- mice with WT BM (n=6); (c) WT mice with TLR4-/- BM (n=7); (d) TLR4-/- mice with TLR4-/- BM (n=6)] were treated with intragastric feeding of alcohol for 4 weeks. Immunohistochemistry against F4/80 (A) are shown (original magnifications are ×100). An F4/80 index was calculated by measuring positive area using Image J software in five high power fields (B). Hepatic mRNA levels of IL-6 and IL-1β were measure by qPCR and are expressed as fold change compared with corresponding pair-fed mice (C, D). Values with different letters are significantly different, p<0.05.