Fig. 3.

The most common temporal paths found in clones that survived to cancer. (A) Each of these common temporal paths comprise on average at least 1% of the neoplasm, and together these 26 paths account for 64% of the cells found in all the cancerous neoplasms. (B) Each mutation is represented by a different color: loss of differentiation (LD) is green, evasion of apoptosis (EA) is purple, limitless replicative potential (LR) is dark blue, sustained angiogenesis (SA) is red, genomic instability (GI) is light blue, self-sufficiency in growth signals (SG) is yellow, and insensitivity to anti-growth signals (IA) is orange.