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Molecular testing results for 228 cases of conventional papillary thyroid cancer
| Group I (n=74) 1991–1995 | Group II (n=103) 1996–2000 | Group III (n=51) 2001–2005 | P-value | |
|---|---|---|---|---|
| Somatic mutation | 68% (51/74) | 64% (66/103) | 92% (47/51) | ≤ 0.002* |
| BRAF mutation | 51% (38/74) | 43% (44/103) | 88% (45/51) | <0.001* |
| RET/PTC1 | 0% | 3% (3/103) | 0% | 0.15 |
| RET/PTC3 | 14% (10/74) | 16% (16/103) | 4% (2/51) | 0.18 |
| NRAS | 1% (1/74) | 1% (1/103) | 0% | 0.44 |
| KRAS | 3% (2/74) | 2% (2/103) | 0% | 0.52 |
For comparison of Group I and or II to Group III.
