Table 3.

Allele frequency of significant genes and their associations with HD risk

		Cases		Controls
		n	%	n	%	P value *	Adjusted OR [95% CI]	P value **
	Subjects analyzed	200	100	220	100
Nucleotide Excision Repair
XPC codon 499						0.01
	Ala/Ala	92	48	137	63
	Ala/Val	90	47	71	33		1.77 [1.17–2.68]	0.01
	Val/Val	8	5	10	5		1.03 [0.38–2.84]	0.95
	At least one Val	98	52	81	38		1.68 [1.13–2.51]	0.01
ERCC1 codon 504						0.17
	Gln/Gln	102	61	122	56
	Gln/Lys	52	31	84	39		0.57 [0.37–0.89]	0.01
	Lys/Lys	14	8	11	5		1.20 [0.51–2.80]	0.68
	At least one Lys	66	39	95	44		0.65 [0.43–0.97]	0.04
Base Excision Repair
XRCC1 codon 194						0.01
	Arg/Arg	183	93	184	84
	Arg/Trp	13	7	32	15		0.39 [0.20–0.79]	0.01
	Trp/Trp	0	0	2	1		0.00 [0.00–3.98]	0.99
	At least one Trp	13	7	34	16		0.37 [0.19–0.74]	0.01
XRCC1 codon 399						0.04
	Arg/Arg	73	37	102	47
	Arg/Gln	106	53	89	41		1.77 [1.16–2.71]	0.01
	Gln/Gln	20	10	28	13		1.13 [0.58–2.18]	0.72
	At least one Gln	126	63	117	53		1.62 [1.08–2.43]	0.02
Other identified genes on DNA repair function
NBN codon 185						0.04
	Glu/Glu	82	42	103	47
	Glu/Gln	102	53	95	43		1.39 [0.93–2.10]	0.11
	Gln/Gln	9	5	22	10		0.49 [0.21–1.17]	0.11
	At least one Gln	111	58	117	53		1.23 [0.83–1.82]	0.31

^*Two-sided χ² test for the difference in the genotype or allele distributions between the cases and the controls

^**Adjusted for age, sex, race, and smoking status in logistic regression models