Table 5.
Cumulative genetic risk score and HD risk
| Cases | Controls | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| n | % | n | % | P value | OR [95%CI] | P value | |||
| 191 | 100 | 215 | 100 | ||||||
| Nucleotide Excision Repair | |||||||||
| 0–2 | 26 | 17 | 44 | 21 | 0.48 | Referent | |||
| 3 | 42 | 28 | 57 | 27 | 1.25 | [0.67–2.34] | 0.49 | ||
| 4+ | 83 | 55 | 108 | 52 | 1.58 | [0.83–3.00] | 0.17 | ||
| Base Excision Repair | |||||||||
| 0–2 | 133 | 70 | 164 | 76 | 0.13 | Referent | |||
| 3 | 48 | 25 | 45 | 21 | 1.32 | [0.53–2.10] | 0.25 | ||
| 4 | 10 | 5 | 6 | 3 | 1.86 | [1.2–5.80] | 0.04 | ||
| Direct reversal of damage | |||||||||
| 0–1 | 151 | 82 | 177 | 82 | |||||
| 2 | 28 | 15 | 32 | 15 | 0.98 | [0.56–1.80] | 0.95 | ||
| 3 | 6 | 3 | 8 | 4 | 0.84 | [0.28–2.50] | 0.76 | ||
| Other identified genes on DNA repair function | |||||||||
| 0–2 | 94 | 53 | 115 | 53 | 0.61 | Referent | |||
| 3 | 57 | 32 | 76 | 35 | 0.92 | [0.60–1.42] | 0.70 | ||
| 4+ | 26 | 15 | 25 | 12 | 1.27 | [0.69–2.35] | 0.44 | ||
| MDR genes | |||||||||
| 0–2 | 82 | 58 | 144 | 69 | 0.02 | Referent | |||
| 3 | 35 | 25 | 54 | 26 | 1.14 | [0.69–1.89] | 0.62 | ||
| 4 | 24 | 17 | 11 | 5 | 3.67 | [1.70–7.91] | 0.01 | ||
| P trend=0.03 | |||||||||
*
Cases and controls were analyzed with adjustment for age, sex, race, and smoking status.