Fig. 2.

Treatment of mice with ISC-4 to determine effects on tumor volume. A, mice were treated with ISC-4, 5-FU, combination, or neither starting one week after injection of tumor cells. Three weeks after tumor cell injection, tumors were measured and volumes shown for each tumor type across all treatment levels. Tumors in mice treated with ISC-4 were smaller than those in mice without ISC-4 (WT alone tumors, p=0.005; WT + Par-4 tumors, p=0.0038; Par-4 tumors, p=0.0193). Tumor volumes were compared for growth rates up through week 4. Nonparametric values at weeks 2, 3, and 4 are: 0.008, 0.0003, and 0.0006, respectively. C, Measurement of time until tumors reached 2 cm at the largest diameter, resulting in euthanasia. D, Mice were weighed once weekly prior to drug injection and weights recorded.