Fig. 3.

Bystander effects of Par-4. A, volume of WT tumors one week after cell injection, prior to treatment. p=0. B, comparison of the wild type tumor weights at euthanasia with the Par-4 tumor weight in the same mouse. Tumors were excised and weighed. The larger Par-4 tumors were present in mice with smaller wild type tumors in an inverse proportional scale. C, time to maximum tumor size of wild type tumors growing alone compared with wild type tumors growing in mice that also had Par-4 tumors. The comparison is made in animals receiving both 5-FU and ISC-4. At the end of 9 weeks, 60% of mice with Par-4 tumors growing in them had wild type tumors less than 2 cm in diameter, while all the tumors growing in mice without Par-4 tumors had reached maximum diameter.