Skip to main content
. Author manuscript; available in PMC: 2012 Jul 15.
Published in final edited form as: J Immunol. 2011 Jun 10;187(2):718–725. doi: 10.4049/jimmunol.1100013

Figure 1. Vagus nerve stimulation prevents lethal endotoxemia.

Figure 1

Mice underwent sham surgery (Control) or vagus nerve stimulation (VNS) started 20 mins before LPS (6mg/Kg, ip). (A) Serum TNF was analyzed by ELISA (n=4; One-way ANOVA with Bonferroni’s corrections). (B) Survival was analyzed for 2 weeks and no late deaths were observed (*p<0.05 vs. control, Logrank survival test; n=15/group). (C) Mice underwent sham surgery (Control) or vagus nerve stimulation (VNS) started 6 hrs after the LPS challenge. Survival was analyzed for 2 weeks and no late deaths were observed (*p<0.05 vs. control, Logrank survival test; n=15/group). (D) Mice underwent sham surgery (Control) or vagus nerve stimulation (VNS) started 6 hrs after the original LPS challenge. Then, animals received a second dose of LPS (2ndLPS), and serum TNF concentrations were measured at 90 mins later (n=4; One-way ANOVA with Bonferroni’s corrections). (E) Splenectomized (SPX) animals underwent sham (Control) or vagus nerve stimulation (VNS) started 20 mins before LPS (6mg/Kg, ip). Survival was analyzed for 2 weeks and no late deaths were observed (*p<0.05 vs. control, Logrank survival test; n=15/group). (F) Control (laparotomy) or splenectomized (SPX) animals underwent sham surgery or vagus nerve stimulation (VNS) and LPS (n=4; One-way ANOVA with Bonferroni’s corrections).