Skip to main content
. Author manuscript; available in PMC: 2013 Jun 1.
Published in final edited form as: Biochim Biophys Acta. 2011 Mar 21;1820(6):743–751. doi: 10.1016/j.bbagen.2011.03.007

Figure 4. Dynamin S-nitrosylation promotes the G protein-coupled receptor internalization.

Figure 4

In the absence of agonist, dynamin tetramers may be bound to eNOS and present in the cytosol. Upon stimulation with agonist, eNOS induces the S-nitrosylation of dynamin that, in turn, promotes the dynamin recruitment to the neck of invaginated pits on the plasma membrane. The S-nitrosylation also increases dynamin self-assembly and its GTPase activity, thereby enhancing rate of vesicle scission from the plasma membrane and internalization of activated receptor.