Table 1.

Overall and stage growth inhibitory activity of currently used antimalarials^a

Compound	Overall IC50 hypoxanthine uptake	Overallb IC50 cytometry	Ringsc IC50 cytometry	Trophozoitesc IC50 cytometry	Schizontsc IC50 cytometry
Chloroquine	311d	123 ± 1.2	219 ± 1.2	111 ± 1.6	70 ± 1.6
Mefloquine	142e	91 ± 1.1	147 ± 1.1	74 ± 1.1	44 ± 1.0
Artemisinin	12f	11 ± 1.1	20 ± 1.2	7 ± 1.1	8 ± 1.0

^aEach flow cytometry assay determination was done in triplicate.

^bOverall IC₅₀ values were determined based upon the number of DNA positive erythrocytes.

^cRing, trophozoite, and schizont IC₅₀ values were calculated based upon the number of each life cycle stages present at each dose of drug. Life cycle stages were determined based upon the level of DNA and RNA within the cell.

^dSaliba et al.¹⁷

^eCowman et al.¹⁸

^fPeel et al.¹⁹