. Author manuscript; available in PMC: 2011 Jul 8.

Published in final edited form as: Bioorg Med Chem Lett. 2009 Jul 23;19(18):5452–5457. doi: 10.1016/j.bmcl.2009.07.095

Table 2.

Overall and stage growth inhibitory activity of compounds from Figure 1 against Plasmodium falciparum strain W2mef

Compound #	% Inhibition at 10 μM^a	IC₅₀ nM^b overall	IC₅₀ nM rings^c	IC₅₀ nM trophozoites^c	IC₅₀ nM schizonts^c
1	87.48	384 ± 1.1	328 ± 1.3	509 ± 1.1	376 ± 1.6
2	85.07	320 ± 1.1	228 ± 1.2	620 ± 1.6	317 ± 1.1
5	91.69	506 ± 1.3	409 ± 1.3	726 ± 1.4	716 ± 1.5
6	49.75	1096 ± 1.2	1197 ± 1.2	1998 ± 1.1	1207 ± 1.1
13	74.90	3769 ± 1.1	1075 ± 1.2	16571 ± 1.5	1998 ± 1.2

This is percent overall parasite growth inhibition.

Overall IC₅₀ values were determined based upon the number of DNA positive erythrocytes.

Ring, trophozoite, and schizont IC₅₀ values were calculated based upon the number of each life cycle stage present at each dose of drug.