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Fluorescence imaging of liver, spleen, kidneys, and heart of control mice and mice sacrificed 1, 4, and 24 h post-injection with (A) Lipid-coated SiNPs and (B) Bare-SiNPs. While an immediate uptake of bare silica particles in the liver was observed, the lipid-coated silica particles accumulated gradually over time in the liver which is in agreement with their prolonged circulation half-life value. Reproduced with permission from [32]® 2008, American Chemical Society.
