Table 1. Biodistribution following subretinal delivery in pigs (GC mdg−1).
| Treatment | Retina | Optic nerve | Chiasm | Thalamus | Visual cortex | ||
|---|---|---|---|---|---|---|---|
| R1 | Left | AAV2/8 | 6.771±0.205 | ND | ND | ND | ND |
| R2 | Left | AAV2/8 | Not measured | ND | ND | ND | ND |
| R3 | Left | AAV2/8 | 2.340±0.043 | ND | ND | ND | ND |
| R4 | Left | AAV2/8 | 2.552±0.126 | ND | ND | ND | ND |
| R5 | Left | AAV2/5 | 4.952±0.379 | ND | ND | ND | ND |
| Right | AAV2/5 | 34.344±0.094 | 0.491±0.005 | ND | ND | ND | |
| R6 | Left | AAV2/5 | 58.104±1.480 | 0.444±0.002 | ND | ND | ND |
| Right | AAV2/5 | Not measured | ND | ND | ND | ND | |
| P3 | Left | AAV2/5-RHO | Not measured | ND | ND | ND | ND |
| Right* | AAV2/5-CMV | Not measured | ND | ND | ND | ND | |
| Right | Not Injected | ND | ND | ND | ND | ND |
Abbreviations: GC, genome copies; mdg, molecule of diploid genome; nd, not detected. Asterisk indicates eye with a retinal detachment.