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Proposed model of NF-κB interactions with different A2AAR and D2R in the striatum. Activation of NF-κB decreases A2AAR expression but up regulates D2R expression and thereby influences the contribution of these receptors to locomotion. Such a model could contribute to differing efficacies of drugs such as caffeine (an antagonist of the A2AAR) and D2R agonists (such as dopamine).
