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Effects of kynurenine metabolites on the nervous structures involved in the pathogenesis of migraine. 7-CK: 7-chlorokynurenic acid, CSD: cortical spreading depression, DRN: dorsal raphe nucleus, IV: fourth ventricle, KYNA: kynurenic acid, LC: locus coeruleus, L-KYN: L-kynurenine, NRM: nucleus raphe magnus, PAG: periaqueductal grey matter, QUIN: quinolinic acid, TG: trigeminal ganglion, TNC: trigeminal nucleus caudalis; ↑: increased concentration.
