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. 2011 May 23;54(13):4559–4580. doi: 10.1021/jm200488a

Table 2. Effects of the Most Potent PIB-SOs, CA-4, and Compound 6 on Cell Cycle Progression, Cytoskeleton Integrity, and Results of a Competition Assay with EBI.

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a

For cell cycle progression, M21 cells were incubated in presence of PIB-SOs at 5 times their respective IC50 for 24 h.

b

For competition assay with EBI, MDA-MB-231 cells were incubated in the presence of PIB-SOs at 1000 times their respective IC50 for 2 h and afterward in the presence of 100 μM EBI for 1.5 h.

c

Inhibition coding: +++, strong inhibition; ++, significant inhibition; +, weak inhibition; −, no inhibition; N/A, not applicable.

d

M21 cells were treated for 16 h with the drug at 5 times their respective IC50, and cellular microtubule structures were visualized using indirect immunofluorescence using an anti-β-tubulin monoclonal antibody.