Table 3. Antiproliferative Activity of Compounds 12, 26, 31, 35, 36, 38, 44–46, 60, Colchicine, Paclitaxel, and Vinblastine on CHO, K562, L1210, P388D1, B16F0, DU-145, HT-1080, MDA-MB-231, SKOV3, and CEM Cells.

	IC50 (nM)d
compd	CHO	K562	L1210	P388D1	B16F0	DU 145	HT-1080	MDA-MB-231	SKOV3	CEM
12	240	240	250	260	510	650	240	760	320	250
26	18	18	21	19	49	57	24	69	29	19
31	73	65	67	76	91	170	65	100	72	68
35	32	18	19	20	65	72	34	55	42	20
36	18	16	17	19	46	58	19	45	22	17
38	17	14	19	18	30	57	19	48	23	17
44	7.3	7.5	6.4	7.8	25	25	8.2	14	6.8	7.1
45	7.4	2.5	5.4	2.7	9.2	8.5	5.9	9.4	6.1	7.1
46	17	7.2	9.6	7.4	41	66	18	26	16	16
60	230	180	140	240	250	550	190	360	210	200
Cola	220	6.8	6.9	28	13	10	1.1	2.9	2.1	7.9
Pacb	170	0.71	0.40	35	28	1.3	0.15	9.1	2.6	0.27
Vblc	17	0.36	0.16	1.8	0.099	0.063	0.099	0.12	0.039	0.38

^aCol, colchicine.

^bPac, paclitaxel.

^cVbl, vinblastine.

^dIC₅₀: concentration of drug inhibiting cell growth by 50%.