TABLE 1.
NOVEL ACUTE LUNG INJURY CANDIDATE GENES IDENTIFIED BY AN EXPANDED CANDIDATE GENE APPROACH: NUMBER OF PUBMATRIX CITATIONS
| Encoded Protein | Gene Symbol | ALI | VILI | ARDS | Vascular Permeability | Inflammation |
|---|---|---|---|---|---|---|
| IL-6 | IL6 | 380 | 79 | 98 | 215 | 12,207 |
| Tissue factor | TF | 696 | 57 | 144 | 1,154 | 12,167 |
| Vascular endothelial growth factor | VEGF | 102 | 46 | 35 | 2,494 | 2,543 |
| IL-1 receptor antagonist | IL1RA | 19 | 4 | 11 | 9 | 1,098 |
| Vascular endothelial growth factor receptor | VEGFR | 30 | 19 | 7 | 992 | 964 |
| Plasminogen activator inhibitor–1 | PAI1 | 66 | 16 | 22 | 32 | 887 |
| IL-13 | IL13 | 12 | 2 | 3 | 11 | 834 |
| Akt, protein kinase B | AKT | 32 | 9 | 3 | 61 | 589 |
| Chemokine receptor–4 | CXCR4 | 13 | 3 | 1 | 2 | 352 |
| Cyclo-oxygenase–2 | COX2 | 5 | 0 | 0 | 3 | 216 |
| Plasminogen activator, urokinase receptor | PAUR | 13 | 1 | 1 | 9 | 196 |
| IL-1b | IL1B | 3 | 0 | 1 | 2 | 183 |
| Pre–B-cell colony enhancing factor | PBEF1 | 17 | 1 | 1 | 5 | 114 |
| Myosin light chain kinase | MYLK | 28 | 6 | 1 | 155 | 85 |
| c-Met | MET | 8 | 1 | 0 | 5 | 58 |
| Aquaporin-1 | AQP1 | 16 | 0 | 6 | 48 | 27 |
| Sphingosine 1-phosphate receptor–1 | EDG1 | 0 | 0 | 0 | 8 | 19 |
| Growth arrest DNA damage–inducible, alpha | GADD45A | 0 | 0 | 0 | 0 | 4 |
Definition of abbreviations: ALI = acute lung injury; ARDS = acute respiratory distress syndrome; VILI = ventilator-induced lung injury.
PubMatrix, a tool for multiplex literature mining (http://pubmatrix.grc.nia.nih.gov/), was used in January 2011.