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Blebbing confers resistance against cell lysis. (1) Plasmalemmal injury: injury – red cylinder; Ca2+ influx – pink circles. (2) Injury-induced bleb formation: myosin-driven contraction – black arrows; cortical cytoskeleton – blue; cytoplasmic annexin A1 – green ovals. (3) Plugged bleb: membrane-bound annexin A1 complexed with Ca2+ (green ovals+pink circles). (4) Spontaneously protruding blebs
