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. 2010 Jun 18;18(1):122–132. doi: 10.1038/cdd.2010.70

Figure 3.

Figure 3

DP-4 competes with DP-1 to downregulate E2F site transcription. (a) U2OS cells were transfected with Cdc6-luciferase (1 μg), together with expression vectors for E2F-1 (100 ng), with DP-4 transfected in increasing amounts (0.1, 0.2, 0.5, 1.0 and 2.0 μg) in the presence of a constant level of DP-1 (2 μg). The relative luciferase activity is shown together with the level of ectopic protein in the lower panel. (b) U2OS cells were transfected with Cdc6-luciferase (1 μg), together with expression vectors for E2F-1 (100 ng), with DP-1 transfected in increasing amounts (0.1, 0.2, 0.5, 1.0 and 2.0 μg) in the presence of a constant level of DP-4 (2 μg). The relative luciferase activity is shown together with the level of ectopic protein in the lower panel