Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Model of involvement of SPP1 in ER stress and UPR and connection to autophagy. Depletion of SPP1 and increased intracellular S1P triggers ER stress and the UPR by activation of ATF6, IRE1α, and PERK, resulting in autophagy. PERK signaling also activates Akt, which protect cells from apoptosis. Other known essential components of ATF6, IRE1α, and PERK that downstream signaling19 are not shown
