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. 2010 Nov 12;18(5):754–768. doi: 10.1038/cdd.2010.143

Figure 7.

Figure 7

Targeted deletion of Light in ALS mice delays progression but not onset of the disease. (a) The cumulative probability of onset of SOD1G93A/Light+/+ (n=12) and SOD1G93A; Light−/− (n=16) was determined by the peak of weight curve. (b) The progressive motor deficit of SOD1G93A/Light+/+, SOD1G93A/Light−/−, Light+/+ and Light−/− was determined by evaluating weekly the swimming performance of mice (values are means±S.E.M.). Statistical attributes are shown only for SOD1G93A/Light+/+ versus SOD1G93A/Light−/− (Supplementary Table). (c) Kaplan–Meier survival curves for SOD1G93A/Light+/+ (n=12) and SOD1G93A/Light−/− (n=14) mice. (d) The mean motoneuron survival was determined by counting the number of VAChT-immunostained motoneurons in 28 sections of lumbar spinal cord from 120-day-old Light+/+ (n=3), Light−/− (n=3), SOD1G93A/Light+/+ (n=4) and SOD1G93A/Light−/− (n=4) (values are means±S.D.)