Table 1. Functional categorization of PIDD-associated proteins identified by proteomics analysis as described in supplemental experimental procedures.

Category	Representative proteins
PIDD	RAIDD/caspase-2
Heat shock/chaperones	—
Replication factor	PCNA/RFC5/POLδ/TEL2 homolog/MCM7
RNA polymerase	RPB2/RPAP3
Elongator complex	PP6
DNA damage/repair	DDB1/FANCI/DNA-PKcs/ XPD/XPG
Histone modification	ANP32B
Apoptosis	HAX1/AIF
Cell cycle	—
Ubiquitination	TRIM32
Sumoylation	SENP3
Nuclear organization/ nucleoporins	NUP93
Regulation of REDOX state	PRDX1
Transcription	—

Only proteins found in all experiments are listed. Data are representative of three independent experiments