Table 3.
Adjusted odds ratios and 95% confidence intervals for associations between knee outcomes, continuous ln Pb and covariates (joint-based analysis)a
| Knee rOA | Knee sxOA | |||
|---|---|---|---|---|
| Variable of interest (reference category) | aORb | 95% CI | aORb | 95% CI |
| ln Pb (per 1-U change) | 1.20 | 1.01 to 1.44 | 1.16 | 0.93 to 1.45 |
| Age (per year) | 1.08 | 1.07 to 1.09 | 1.05 | 1.03 to 1.06 |
| BMI (per kg/m2) | 1.12 | 1.10 to 1.14 | 1.12 | 1.10 to 1.14 |
| Sex (men) | 0.96 | 0.77 to 1.21 | 1.24 | 0.94 to 1.63 |
| Race (Caucasian) | 1.08 | 0.85 to 1.36 | 0.84 | 0.64 to 1.11 |
| Smoking (No) | 0.60 | 0.43 to 0.85 | 0.59 | 0.38 to 0.91 |
| Drinking (No) | 0.75 | 0.57 to 1.00 | 0.72 | 0.50 to 1.03 |
aReference category is no rOA for rOA outcomes and rOA without symptoms for sxOA outcomes; aOR, adjusted odds ratio; CI, confidence interval; ln Pb, natural log-transformed lead; rOA, radiographic osteoarthritis; sxOA, symptomatic osteoarthritis; BMI, body mass index; badjusted for age, sex, race and ethnicity, BMI, current smoking and current drinking.