Table 2.
Distribution of phenotypic frequencies of HLA-A alleles
| All subjects | OR (95% CI) |
P
(Pc) |
HLA-B*51 non-carriers | OR (95% CI) |
P
(Pc) |
HLA-B*51 carriers | OR (95% CI) |
P
(Pc) |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BD N = 223 |
Control N = 1,398 |
BD N = 142 |
Control N = 1,116 |
BD N = 81 |
Control N = 282 |
|||||||||||||
| A*01:01 | 2 | (0.9) | 45 | (3.2) | 0.27 (0.07 to 1.13) |
2 | (1.4) | 38 | (3.4) | 0.41 (0.10 to 1.70) |
0 | (0.0) | 7 | (2.5) | NA | |||
| A*02:01 | 77 | (34.5) | 433 | (31.0) | 1.18 (0.87 to 1.58) |
46 | (32.4) | 359 | (32.2) | 1.01 (0.70 to 1.47) |
31 | (38.3) | 74 | (26.2) | 1.74 (1.04 to 2.93) |
0.035 (> 1.0) |
||
| A*02:03 | 4 | (1.8) | 19 | (1.4) | 1.33 (0.45 to 3.93) |
3 | (2.1) | 19 | (1.7) | 1.25 (0.36 to 4.26) |
1 | (1.2) | 0 | (0.0) | NA | |||
| A*02:05 | 0 | (0.0) | 1 | (0.1) | NA | 0 | (0.0) | 1 | (0.1) | NA | 0 | (0.0) | 0 | (0.0) | NA | |||
| A*02:06 | 35 | (15.7) | 250 | (17.9) | 0.85 (0.58 to 1.26) |
18 | (12.7) | 193 | (17.3) | 0.69 (0.41 to 1.17) |
17 | (21.0) | 57 | (20.2) | 1.05 (0.57 to 1.93) |
|||
| A*02:07 | 27 | (12.1) | 89 | (6.4) | 2.03 (1.28 to 3.20) |
0.002 (0.06) |
19 | (13.4) | 80 | (7.2) | 2.00 (1.17 to 3.41) |
0.010 (> 1.0) |
8 | (9.9) | 9 | (3.2) | 3.32 (1.24 to 8.92) |
0.031 (> 1.0) |
| A*02:10 | 0 | (0.0) | 13 | (0.9) | NA | 0 | (0.0) | 12 | (1.1) | NA | 0 | (0.0) | 1 | (0.4) | NA | |||
| A*03:01 | 3 | (1.4) | 35 | (2.5) | 0.53 (0.16 to 1.74) |
3 | (2.1) | 28 | (2.5) | 0.84 (0.25 to 2.79) |
0 | (0.0) | 7 | (2.5) | NA | |||
| A*03:02 | 1 | (0.5) | 6 | (0.4) | 1.05 (0.13 to 8.72) |
1 | (0.7) | 5 | (0.5) | 1.58 (0.18 to 13.59) |
0 | (0.0) | 1 | (0.4) | NA | |||
| A*11:01 | 39 | (17.5) | 242 | (17.3) | 1.01 (0.70 to 1.47) |
25 | (17.6) | 188 | (16.9) | 1.05 (0.67 to 1.67) |
14 | (17.3) | 54 | (19.2) | 0.88 (0.46 to 1.69) |
|||
| A*11:02 | 2 | (0.9) | 2 | (0.1) | 6.32 (0.89 to 45.08) |
1 | (0.7) | 1 | (0.1) | 7.91 (0.49 to 127 to 13) |
1 | (1.2) | 1 | (0.4) | 3.5 (0.22 to 56.58) |
|||
| A*24:02 | 95 | (42.6) | 578 | (41.3) | 1.05 (0.79 to 1.40) |
54 | (38.0) | 442 | (39.6) | 0.94 (0.65 to 1.34) |
41 | (50.6) | 136 | (48.2) | 1.10 (0.67 to 1.80) |
|||
| A*24:03 | 0 | (0.0) | 1 | (0.1) | NA | 0 | (0.0) | 1 | (0.1) | NA | 0 | (0.0) | 0 | (0.0) | NA | |||
| A*24:04 | 0 | (0.0) | 1 | (0.1) | NA | 0 | (0.0) | 1 | (0.1) | NA | 0 | (0.0) | 0 | (0.0) | NA | |||
| A*24:08 | 0 | (0.0) | 1 | (0.1) | NA | 0 | (0.0) | 1 | (0.1) | NA | 0 | (0.0) | 0 | (0.0) | NA | |||
| A*24:20 | 1 | (0.5) | 2 | (0.1) | 3.14 (0.28 to 34.82) |
1 | (0.7) | 2 | (0.2) | 3.95 (0.36 to 43.84) |
0 | (0.0) | 0 | (0.0) | NA | |||
| A*26:01 | 26 | (11.7) | 93 | (6.7) | 1.85 (1.17 to 2.93) |
0.008 (0.24) |
19 | (13.4) | 74 | (6.6) | 2.18 (1.27 to 3.72) |
0.004 (0.12) |
7 | (8.6) | 19 | (6.7) | 1.31 (0.53 to 3.23) |
|
| A*26:02 | 11 | (4.9) | 58 | (4.2) | 1.20 (0.62 to 2.32) |
7 | (4.9) | 46 | (4.1) | 1.21 (0.53 to 2.73) | 4 | (4.9) | 12 | (4.3) | 1.17 (0.37 to 3.72) |
|||
| A*26:03 | 7 | (3.1) | 17 | (1.2) | 2.63 (1.08 to 6.42) |
0.037 (> 1.0) |
5 | (3.5) | 14 | (1.3) | 2.87 (1.02 to 8.10) |
0.053 | 2 | (2.5) | 3 | (1.1) | 2.35 (0.39 to 14.34) |
|
| A*26:05 | 0 | (0.0) | 1 | (0.1) | NA | 0 | (0.0) | 0 | (0.0) | NA | 0 | (0.0) | 1 | (0.4) | NA | |||
| A*26:18 | 0 | (0.0) | 1 | (0.1) | NA | 0 | (0.0) | 1 | (0.1) | NA | 0 | (0.0) | 0 | (0.0) | NA | |||
| A*29:01 | 2 | (0.9) | 28 | (2.0) | 0.44 (0.10 to 1.87) |
2 | (1.4) | 24 | (2.2) | 0.65 (0.15 to 2.78) |
0 | (0.0) | 4 | (1.4) | NA | |||
| A*29:02 | 1 | (0.5) | 0 | (0.0) | NA | 1 | (0.7) | 0 | (0.0) | NA | 0 | (0.0) | 0 | (0.0) | NA | |||
| A*30:01 | 8 | (3.6) | 74 | (5.3) | 0.67 (0.32 to 1.40) |
7 | (4.9) | 63 | (5.7) | 0.87 (0.39 to 1.93) |
1 | (1.2) | 11 | (3.9) | 0.31 (0.04 to 2.42) |
|||
| A*30:04 | 12 | (5.4) | 31 | (2.2) | 2.51 (1.27 to 4.96) |
0.006 (0.18) |
11 | (7.8) | 26 | (2.3) | 3.52 (1.70 to 7.29) |
0.002 (0.06) |
1 | (1.2) | 5 | (1.8) | 0.69 (0.08 to 6.01) |
|
| A*31:01 | 22 | (9.9) | 160 | (11.4) | 0.85 (0.53 to 1.35) |
10 | (7.0) | 98 | (8.8) | 0.79 (0.40 to 1.55) |
12 | (14.8) | 62 | (22.0) | 0.62 (0.31 to 1.21) |
|||
| A*31:11 | 0 | (0.0) | 1 | (0.1) | NA | 0 | (0.0) | 0 | (0.0) | NA | 0 | (0.0) | 1 | (0.4) | NA | |||
| A*32:01 | 0 | (0.0) | 26 | (1.9) | NA | 0 | (0.0) | 25 | (2.2) | NA | 0 | (0.0) | 1 | (0.4) | NA | |||
| A*33:03 | 43 | (19.3) | 405 | (29.0) | 0.59 (0.41 to 0.83) |
0.003 (0.09) |
33 | (23.2)† | 345 | (30.9) | 0.68 (0.45 to 1.02) |
10 | (12.4) | 60 | (21.3) | 0.52 (0.25 to 1.07) |
||
| A*68:01 | 1 | (0.5) | 3 | (0.2) | 2.09 (0.22 to 20.23) |
1 | (0.7) | 2 | (0.2) | 3.95 (0.36 to 43.85) |
0 | (0.0) | 1 | (0.4) | NA | |||
Values are presented as N (%). P (Pc) values are presented for those alleles with estimable OR (95% CI) and P-values of < 0.05.
†P = 0.047 (HLA-B*51 negative vs. positive patients). BD, Behcet's disease; CI, confidence intervals; NA, not applicable; OR, odds ratio; Pc, corrected P