Table 2.
Synovial fluid concentrations of the biological markers in patients with OA or RA and in asymptomatic organ donorsa
| P values | ||||||
|---|---|---|---|---|---|---|
| Marker | Donor (n = 20) | OA (n = 45) | RA (n = 22) | OA vs. donor | RA vs. donor | OA vs. RA |
| IL-6, pg/mL | 86.97 (82.0) | 119.4 (193.2) | 354.7 (1851.6) | 0.4 | 0.0011 | 0.0026 |
| IL-8, pg/mL | 451 (170.7) | 429 (87.3) | 583.6 (1086.4) | 0.0809 | 0.016 | <0.0001 |
| IL-11, pg/mL | 211.6 (40.8) | 296.2 (257.2) | 217.5 (178) | 0.0067 | 0.4557 | 0.2393 |
| IL-1, pg/mL | 9.08 (1.6) | 7.76 (2.6) | 9.26 (11.1) | 0.02 | 0.9318 | 0.0497 |
| OP-1, ng/mL | 54.49 (29.3) | 81.79 (116.0) | 167.1 (194.8) | <0.0001 | <0.0001 | 0.0013 |
| LIF, pg/mL | 228.5 (131.6) | 107.5 (136.9) | 128.4 (222.7) | 0.0063 | 0.139 | 0.1991 |
| Osteo, ng/mL | 2.58 (6.6) | 2.515 (4.9) | 1.99 (3.9) | 0.7437 | 0.893 | 0.5384 |
| COMP, U/L | 413.2 (339.9) | 490.2 (207.5) | 507.3 (352.9) | 0.4652 | 0.3102 | 0.3865 |
aOA, osteoarthritis; RA, rheumatoid arthritis; IL, interleukin; OP-1, osteogenic protein 1; LIF, leukemia-inhibitory factor; Osteo, osteocalcin; COMP, cartilage oligomeric protein. Absolute values of biomarkers detected in synovial fluid of patients with osteoarthritis, rheumatoid arthritis and asymptomatic organ donors. P values were calculated by using an unpaired, two-tailed Mann-Whitney t-test with 95% confidence interval. Values are expressed as medians (interquartile ranges).