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The anti-CII IgG antibody titers are elevated in the cystatin C-deficient mice. Mice were bled at Day 34 (A) before boost immunization with CII/IFA, and at the end of the experiment at Day 115 (B). There was a statistically significant difference between the antibody production of cystatin C-deficient mice (Cyst C -/-) and the wild type controls (Cyst C +/+) at Day 115. ** P-value < 0.01 as tested with Mann-Whitney.
