Table 7.
Changes in the expression of TGF-β/BMP family related genes, their receptors, and signaling regulators
| rhOP-1 vs Cntr | rhOP-1AS vs Cntr | ||
|---|---|---|---|
| fold change | fold change | Accession no. | |
| GDF-15 | 3.04↓ | 2.03↑ | [GenBank:NM_004864] |
| BMP-2 | 2.67↓ | [GenBank:NM_001200] | |
| Inhibin-βa (activin A) | 2.32↓ | 2.15↑ | [GenBank:NM_002192] |
| BMP-2 inducible kinase | 1.61↓ | [GenBank:NM_017593] | |
| Parathyroid hormone-like hormone | 1.60↓ | 2.17↑ | [GenBank:NM_002820] |
| ID2 | 2.32↓ | [GenBank:NM_002166] | |
| Notch 4 | 2.32↓ | [GenBank:NM_004557] | |
| MAD-6 | 2.05↓ | [GenBank:NM_005585] | |
| Gremlin | 1.88↑ | 1.94↓ | [GenBank:NM_013372] |
| GDF-10 | 1.86↓ | [GenBank:NM_004962] | |
| ID4 | 1.82↑ | 1.84↓ | [GenBank:NM_001546] |
| ID3 | 1.73↓ | [GenBank:NM_002167] | |
| MAD interacting protein | 1.69↓ | [GenBank:NM_004799] | |
| MAD-4 | 1.67↓ | [GenBank:NM_005359] | |
| Notch 1 | 1.65↓ | [GenBank:NM_017617] | |
| MAD-7 | 1.62↓ | [GenBank:NM_005904] | |
| TGF-α | 1.54↓ | ||
| Receptors | |||
| Frizzled homolog 10 (Drosophila) | 1.57↓ | [GenBank:NM_007197] | |
| Activin-α RI | 1.53↓ | [GenBank:NM_001105] | |
| Activin A-RIIB | 2.42↓ | [GenBank:NM_001106] | |
| BMPR1A | 1.83↓ | [GenBank:NM_004329] | |
| TGF-βRI | 1.51↓ | [GenBank:NM_004612] | |
| TGF-βRIII | 1.50↓ | [GenBank:NM_003243] | |
| TGF-β R2 | 1.58↑ | [GenBank:NM_003242] | |
| Activin A-RIB | 1.53↑ | [GenBank:NM_004302] | |
| Bone formation | |||
| Osteomodulin | 1.78↑ | 2.56↓ | [GenBank:NM_005014] |