Table 8.
Association between OP-1 and other growth factors including igf-1, insulin, and tyrosine-kinase signaling
| rhOP-1 vs Cntr | OP-1AS vs Cntr | |
|---|---|---|
| fold change | fold change | |
| IGF-BP1 | 2.17↓ | |
| Nerve growth factor-β | 1.93↓ | |
| VEGF-β | 1.62↓ | 1.50↓ |
| Endothelial cell growth factor 1 (platelet-derived) | 1.56↓ | |
| VEGF | 1.52↓ | |
| Capillary morphogenesis protein 1 | 1.52↓ | |
| FGF-7 | 2.87↓ | |
| FGF-R2 | 1.69↑ | 2.83↓ |
| IGF-BP5 | 1.90↓ | |
| FGF-R3 | 1.87↑ | 1.80↓ |
| IGF-1R | 1.73↓ | |
| PDGF-Rα | 1.62↑ | 1.70↓ |
| PDGF-Rβ | 1.68↓ | |
| IGF-BP7 | 1.58↓ | |
| IRS2 (insulin receptor substrate 2) | 2.10↓ | 1.70↑ |
| DPYSL2 (dihydropyrimidinase-like 2) | 1.60↑ | 1.60↓ |
| MET (hepatocyte growth factor receptor) | 1.70↓ | 1.60↑ |
| SPRY2: sprouty homolog 2 (Drosophila) | 1.60↓ | 1.60↑ |
| SORBS1: sorbin and SH3 domain containing 1 | 1.70↑ | 1.50↓ |
| PIK3R1 (Phosphoinositide-3-kinase, regulatory subunit 1) | 1.72↑ | |
| MAP2K2 (mitogen-activated protein kinase kinase 2) | 1.61↑ | |
| PDE3B (phosphodiesterase 3B, cGMP-inhibited) | 2.00↑ | |
| SOCS3 (suppressor of cytokine signaling 3) | 1.79↑ |