Table 2.
Functional categorization of genes differentially expressed between SAID probands and unrelated, matched controls
| Immune | Signaling | Gene expression | Metabolism | Transport | Structural | Cell cycle | Other/Unknown |
|---|---|---|---|---|---|---|---|
| TNFAIP6 | ANXA3 | EIF2AK2 | DEGS1 | HP | HIST1H2AB | NELL2 | ZCCHC2 |
| PLSCR1 | APOBEC3A | PBX4 | CDS2 | HPR | KRTCAP2 | DVL1 | RNF220 |
| LTF | BMX | ZBTB5 | PECI | SLC22A4 | SPOCK2 | ANAPC5 | LDOC1L |
| TNFSF10 | CEACAM6 | PABPC3 | DNMT1 | DNAJA3 | SEMA4C | DDB1 | |
| IFI27 | OASL | EIF3S6IP | ATP5G2 | CRIP1 | ERGIC3 | ||
| IL1RN | MAP2K6 | EIF3S8 | POLS | STAG3 | |||
| FCER1A | INHBB | RBMX | MFNG | ||||
| SYTL2 | DEFA4 | ZNF219 | PRPSAP2 | ||||
| CD99 | RRAGD | IMP3 | PTDSS1 | ||||
| CD81 | PGAP1 | AOF2 | AKR1B1 | ||||
| GZMK | PACSIN1 | MTA1 | |||||
| LTK | FYN | UXT | |||||
| KLRB1 | DYRK2 | RPL18 | |||||
| TNFRSF25 | LOC100133315 | DDX28 | |||||
| CXCR3 | GPRASP1 | SRP46 | |||||
| STMN3 | EIF3S7 | ||||||
| ATP1A1 | MYBL1 | ||||||
| PSBP | PABPC1 | ||||||
| UBE2I | AES | ||||||
| LGR6 | RPLP2 | ||||||
| TC2N | FBL | ||||||
| GPR183 | RPS19 | ||||||
| CSNK1E | |||||||
| ARIH2 | |||||||
| PUF60 | |||||||
| FBXO21 | |||||||
| F5 |
SAID, systemic autoimmune disease.