Table 5.
HIV-1-Neutralizing Activity in Plasma and CVL
|
Laboratory A |
Laboratory E |
Laboratory F |
|||||||
---|---|---|---|---|---|---|---|---|---|---|
|
NL4.3 |
CC.1 |
NL4.3 |
JRCSF |
SF162 |
aMLV |
||||
Plasma | CVL | Plasma | CVL | Plasma | Plasma | Plasma | CVL | Plasma | CVL | |
HIV-1 infected subjects | ||||||||||
1 | 1,000 | 12 | <60 | – | 2,586 | 87 | 5,846 | <10 | 2,586 | <10 |
2 | 1,620 | 12 | <60 | – | 7,271 | 96 | 25,870 | 24 | <20 | <10 |
3 | 540 | – | <60 | – | 2,442 | 807 | 19,884 | <10 | 23 | <10 |
4 | 540 | – | <60 | – | 1,683 | 50 | 2,549 | <10 | 25 | <10 |
5 | 120 | – | <60 | >17.1 | 562 | 84 | 5,155 | 13 | 20 | <10 |
6 | 540 | – | <60 | – | 2,113 | 656 | 5,479 | <10 | 278 | <10 |
7 | 180 | nd | <60 | 14.3 | 1,334 | 400 | 10,474 | <10 | 25 | <10 |
8 | 1,000 | – | <60 | – | 3,805 | 141 | 22,693 | 22 | 54 | 18 |
9 | 180 | – | <60 | nd | 966 | 53 | 4,891 | 43 | 29 | <10 |
10 | 180 | – | <60 | – | 545 | 82 | 3,709 | <10 | <20 | <10 |
11 | 360 | nd | <60 | – | 662 | 140 | 1,045 | <10 | <20 | <10 |
12 | 180 | – | <60 | – | 638 | 443 | 1,100 | 13 | 23 | <10 |
13 | 180 | – | <60 | – | 179 | 157 | 1,343 | <10 | 26 | <10 |
14 | 300 | – | <60 | – | 794 | 33 | 737 | 51 | 30 | 25 |
15 | 180 | – | 111.2 | – | 477 | 82 | 12,790 | <10 | 36 | <10 |
16 | 60 | – | <60 | – | 474 | 41 | 2,236 | 39 | 22 | <10 |
17 | 180 | 54 | <60 | >17.1 | 1,056 | 108 | 9,851 | <10 | <20 | <10 |
18 | 60 | – | <60 | >17.1 | 532 | 58 | 2,282 | <10 | 32 | <10 |
19 | 180 | – | 80.0 | – | 1,846 | 675 | 4,304 | 30 | 367 | <10 |
20 | 180 | – | <60 | – | 1,135 | 45 | 11,213 | <10 | <20 | <10 |
21 | 180 | – | <60 | – | 507 | 79 | 568 | <10 | <20 | <10 |
22 | 1,000 | – | <60 | – | 7,270 | 190 | 8,292 | <10 | 29 | <10 |
23 | 180 | – | <60 | – | 819 | 644 | 2,994 | <10 | 22 | <10 |
24 | 60 | – | 126.8 | – | 315 | 58 | 1,750 | <10 | <20 | <10 |
25 | 500 | – | <60 | 10.0 | 1,126 | 207 | 8,434 | 17 | <20 | <10 |
26 | 500 | – | <60 | – | 1,161 | 435 | 2,605 | 28 | 32 | <10 |
HEPSN subjects | ||||||||||
1 | – | – | <60 | – | 38 | 41 | 30 | 290 | 28 | <10 |
2 | – | – | <60 | – | 29 | 23 | 37 | <10 | 30 | <10 |
3 | – | – | <60 | nd | 33 | 23 | 25 | 92 | <20 | <10 |
4 | – | – | <60 | – | 48 | 33 | 35 | <10 | 36 | <10 |
5 | – | – | <60 | – | 31 | <20 | 73 | <10 | 21 | <10 |
6 | – | – | <60 | – | 47 | 26 | 31 | 12 | 30 | <10 |
7 | – | – | <60 | nd | 22 | <20 | 22 | <10 | <20 | <10 |
8 | – | – | <60 | – | 40 | 24 | 22 | <10 | <20 | <10 |
9 | – | – | <60 | – | 27 | 22 | 20 | <10 | 21 | <10 |
10 | 60 | nd | <60 | >17.1 | 32 | 27 | 23 | <10 | <20 | <10 |
11 | 60 | – | <60 | – | 21 | 30 | 29 | 13 | 21 | <10 |
12 | 60 | – | <60 | – | 28 | <20 | 23 | <10 | <20 | <10 |
13 | – | – | <60 | – | 34 | <20 | 24 | <10 | 28 | <10 |
14 | – | – | <60 | – | 28 | 24 | 39 | 16 | 23 | <10 |
15 | – | – | <60 | – | 38 | 26 | 33 | 63 | 34 | <10 |
16 | – | – | <60 | – | <20 | <20 | 30 | <10 | 30 | <10 |
17 | – | – | <60 | – | 23 | 21 | 34 | 13 | 30 | <10 |
18 | – | – | <60 | – | <20 | <20 | <20 | <10 | <20 | <10 |
19 | – | – | <60 | >17.1 | 42 | 31 | 32 | 17 | 28 | <10 |
20 | – | – | <60 | >17.1 | 35 | <20 | 21 | <10 | 30 | <10 |
21 | – | – | <60 | – | <20 | <20 | 22 | 11 | <20 | <10 |
22 | – | – | <60 | – | 21 | 22 | <20 | <10 | <20 | <10 |
23 | – | – | <60 | – | <20 | <20 | <20 | <10 | <20 | <10 |
24 | – | – | <60 | – | <20 | <20 | 22 | 11 | <20 | <10 |
25 | – | – | <60 | – | 41 | 27 | 24 | <10 | 33 | <10 |
26 | – | – | <60 | – | 27 | <20 | 32 | <10 | 26 | <10 |
27 | – | – | <60 | – | 26 | 22 | 32 | 75 | 26 | <10 |
28 | – | – | <60 | – | 287 | 136 | 696 | 31 | 23 | 11 |
29 | – | – | <60 | – | 27 | 21 | <20 | 42 | 22 | <10 |
30 | – | – | <60 | – | 26 | 23 | 27 | <10 | 20 | <10 |
31 | – | – | <60 | – | 36 | 23 | 24 | 11 | 27 | <10 |
32 | – | – | <60 | – | <20 | <20 | 23 | 20 | <20 | <10 |
33 | – | – | <60 | – | 25 | 23 | 24 | <10 | <20 | <10 |
34 | – | – | <60 | – | 27 | <20 | 27 | <10 | <20 | <10 |
35 | – | – | <60 | – | 28 | <20 | 21 | <10 | <20 | <10 |
36 | – | – | <60 | – | 63 | 65 | 62 | 33 | 36 | <10 |
37 | – | – | <60 | – | 20 | 21 | 22 | 12 | <20 | <10 |
38 | – | – | <60 | – | 29 | 24 | 29 | 15 | 27 | <10 |
39 | 60 | – | <60 | – | 29 | 33 | 36 | 13 | 23 | <10 |
40 | – | – | <60 | – | 30 | 26 | 28 | <10 | 31 | <10 |
41 | – | – | <60 | – | <20 | <20 | <20 | 11 | <20 | <10 |
The values shown represent the last reciprocal dilution that inhibited viral infection by 50% as described for each laboratory in the Materials and Methods. Dashes denote samples which failed to neutralize virus. nd: not done.