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. Author manuscript; available in PMC: 2012 Apr 1.
Published in final edited form as: Traffic. 2011 Feb 1;12(4):483–498. doi: 10.1111/j.1600-0854.2010.01155.x

Figure 1. Models of MCT sorting in different epithelia.

Figure 1

In RPE cells, MCT1/CD147 is polarized to the apical and MCT3/CD147 to the basolateral membrane. In wild-type MDCK cells, all MCT/CD147 complexes are sorted basolaterally. When rCD147-L252A is expressed in MDCK cells, MCT1/ rCD147-L252A complexes are localized to the apical membrane while MCT1/CD147 complexes are basolateral. In contrast, endogenously expressed MCT4 or exogenously expressed MCT3 remain basolateral whether they are complexed with endogenous CD147 or with exogenously expressed rCD147-L252A, indicating that MCT3 and MCT4 both harbor BLSS.