Figure 3.

Mean fold change (± SEM) in 6q27 gene expression levels in splenic aspirates from Indian patients with visceral leishmaniasis (n = 12) relative to those in the normal spleen sample (n = 1). A 1-sample T test was used to compare expression levels for each gene in visceral leishmaniasis case aspirates against those in the control spleen sample as a population mean. DLL1 expression was significantly (P = 2 × 10⁻⁷) reduced (mean fold change, 3.5 [SEM, 0.7]) in splenic aspirates from patients with visceral leishmaniasis, whereas other 6q27 genes showed higher levels (1.27 × 10⁻⁶ < P < .01) than those in the control spleen sample.