Table-1.
Lipids and Fatty Acid Metabolic Genes Annotated in GS, WB and P15 Isolates in Giardia
| Classification | Homologues | NCBI Accession Number | GiardiaDB ORF | ||
|---|---|---|---|---|---|
| 50803 (WB) | 50581 (GS) | 50803 (WB | P15 | ||
| Phospholipid | PI Synthase/CDP-DAG-inositol 3-phosphatidyltransferase (gPIS) | XP_001707169 | 831 | 9829 | 1650 |
| PI transfer protein alpha isoform (PITPα) | XP_001705528 | 3968 | 4197 | 2564 | |
| PGP synthase/CDP-DAG-glycerol-3-phosphate-3- phosphatidyltransferase (gPGPS) | XP_001707005 | 4006 | 7529 | 1650 | |
| PS decarboxylase (gPSD) | XP_001707910 | 1294 | 16495 | 5211 | |
| PS synthase (gPSS) | XP_001707737 | 928 | 17427 | 660 | |
| Phospholipid-transporting ATPase IA, putative (gPLTATPase 1A) | XP_001704967, XP_001710085 | 177, 3570 | 8182, 16958, 10019 | 2350, 2846, 1870 | |
| Phospholipid-transporting ATPase IIB, putative (gPLTATPase IIB) | XP_001704293, XP_001707954 | 900, 2201 | 137725, 101810, 38104 | 2493, 1733 | |
| Fatty Acid | 1-acyl-sn-glycerol-3-phosphate acyl transferase (gAGPAT4) | XP_001704656 | 7126 | ||
| gAGPAT3 | XP_001704595 | 2692 | |||
| gAGPAT2 | XP_001707326 | 12109 | |||
| Lysophosphatidic acid acyltransferase, putative (gLPAAT) | XP_001707002 | 4004 | 14403 | 1652 | |
| Fatty acid elongase 1 (gFAELO) | XP_001708101 | 2228 | 92729 | 536 | |
| Long chain fatty acid CoA ligase 5 (gLCFACL5) | XP_001705891, XP_001705009, XP_001706424, XP_001707853 | 2104, 2579, 2829, 3493 | 9062, 2118, 15063, 17170 | 2620, 2964, 109, 5157 | |
| Long chain fatty acid CoA ligase 4 (gLCFACL5) | XP_001708520 | 3754 | 30476 | 1330 | |
| Long chain fatty acid CoA ligase, putative (gLCFACL) | XP_001709411 | 113892 | 4443 | ||
| Acetyl-CoA carboxylase (gACC)/pyruvate carboxylase fusion protein, putative | XP_001705655 | 1829 | 113021 | 184 | |
| Sterol | Lecithin-cholesterol acyl transferase, putative (gLCCAT) | XP_001705338, XP_001706263 | 1681, 4525 | 5746, 16286 | 297, 1123 |
| Neutral Lipid | Phospholipase B (gPLB) | XP_001704922, XP_001709220 | 128, 380 | 93548, 17277 | 2398, 711, 1744 |
| Sphingolipids | Ceramide glucosyltransferase (gGlcT1) | XP_001704299 | 2206 | 11642 | 1728 |
| Acid sphingomyelinase-like phosphodiesterase 3b (gASMase) | XP_001709364, XP_001705202 | 370, 4397 | 16737, 8360 | 757, 809 | |
| Serine palmitoyltransferase-1(gSPT1) | XP_001707207 | 798 | 23015 | 2116 | |
| Serine palmitoyltransferase-2 (gSPT2) | XP_001704960 | 1960 | 14374 | 1863 | |
| Signaling Lipids | Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase (gPI3Pase) | XP_001709198 | 1218 | 16728 | 1550 |
| Type II inositol-1,4,5-trisphosphate 5-phosphatase precursor (gITP5Pase) | XP_001705945 | 3898 | 14787 | 3004 | |
| Inositol 5-phosphatase 4 (gI5Pase) | XP_001709238 | 146 | 9077 | 363 | |
| Phosphoinositide-3-kinase, class 3 (gPI3K) | XP_001708644 | 2073 | 17406 | 3357 | |
| PI-3-kinase, catalytic, alpha polypeptide (gPI3Kα) | XP_001709235 | 144 | 14855 | 361 | |
| Phosphatidylinositol-4-phosphate 5-kinase, putative (gPI4P5K) | XP_001709292, XP_001705538 XP_001707008, XP_001705604, XP_001709854, XP_001710017 | 649, 950, 1909, 3977, 4008, 4088 | 14628, 24712, 7261, 2622, 13606, 11897 | 2573, 606, 2900, 1648, 4395, 2048 | |
| PI-4-kinase (gPI4K) | XP_001706660 | 1085 | 16558 | 1075 | |
| Phosphatidylinositol-glycan biosynthesis, class O protein (gPIG) | XP_001709629 | 1892 | 14975 | 2782 | |