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. Author manuscript; available in PMC: 2011 Dec 1.
Published in final edited form as: Pediatr Res. 2010 Dec;68(6):519–525. doi: 10.1203/PDR.0b013e3181f90278

Figure 8. Effects of hyperoxia and L-citrulline treatment on protein abundance of arginase II and arginase activity in P7 rat lung homogenates.

Figure 8

(A) Representative western blots of three separate studies performed on a total of 6 untreated (lane 1–2) and citrulline-treated (lane 3–4) normoxic and untreated (lane 5–6) and citrulline-treated (lane 7–8) hyperoxic neonatal rat lungs. (B) Summary densitometry showing that both hyperoxia and L-citrulline independently and synergistically increased arginase II expression in neonatal rat lungs. *P<0.05 different than normoxia; **P<0.05 different from all other groups. (C) L-Citrulline decreases pulmonary arginase activity in O2-induced BPD in newborn rats. Hyperoxic exposed rats had significantly increased lung arginase activity on postnatal day 7 (P7). L-Citrulline normalized lung arginase activity in hyperoxic exposed rats. Arginase activity was unchanged in L-citrulline treated control rats. N=5/group, *P<0.05.