Table 1.
Characteristics of the study population by mutation status
| Premutation | Non-carriers | Total | |||
|---|---|---|---|---|---|
| Nijmegen | Atlanta | Nijmegen | Atlanta | ||
| Age at ascertainment (yrs) | 56.4 | 49.6 | 54.6 | 52.7 | 53.0 |
| Age at menopause (yrs) | |||||
| - Well defined | 42.5 | 43.5 | 48.3 | 49.9 | 45.9 |
| (%) | (72%) | (34%) | (58%) | (25%) | (42%) |
| - Censored | 41.7 | 39.0 | 42.9 | 42.2 | 41.0 |
| (%) | (28%) | (66%) | (42%) | (75%) | (58%) |
| Menarche (yrs) | 13.2 | 12.4 | 13.1 | 12.5 | 12.7 |
| Parity | 2.2 | 2.1 | 2.0 | 2.1 | 2.1 |
| Ever used hormones (%) | 79% | 80% | 74% | 85% | 80% |
| Ever smoking (%) | 41% | 36% | 35% | 40% | 38% |
| BMI | 24.6 | 27.0 | 25.8 | 27.2 | 26.5 |
| Ascertainment (N) | |||||
| - Fragile X family, USA | 370 | 183 | 51.7% | ||
| - General population, USA | 3 | 127 | 12.2% | ||
| - Fragile X family, NL | 144 | 241 | 36.1% | ||