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. Author manuscript; available in PMC: 2012 Jul 1.
Published in final edited form as: Cancer Epidemiol Biomarkers Prev. 2011 May 17;20(7):1543–1551. doi: 10.1158/1055-9965.EPI-10-1248

Figure 2.

Figure 2

Receiver operator characteristic (ROC) curves from single assays for amphiregulin (AmR), epidermal growth factor (EGF), heparin binding epidermal growth factor (HB-EGF), matrix metalloprotease 9 (MMP9), and RANTES, all of which are significantly altered in patients with breast cancer in subjects with either ER+/HER2- tumors (left column) or ER-/HER2+ tumors (right column). Each graph contains step (empirical) and smooth (fitted, parametric) ROC curves, and a grey shaded area that presents the 90% confidence intervals of the fitted curve, as generated by Monte Carlo analysis.