Table 2.

Serum levels of inflammatory biomarkers

	PLAC (N = 33)	ACET (N = 33)	FLUV (N = 30)
IL-6 (pg/ml): median (min, max)a
Baseline	2.0 (1, 61)	2.1 (0, 31)	2.5 (0, 8)
24 h	14.5 (2, 154)	9.7 (2, 73)	14.8 (2, 79)
72 h	3.9 (1, 160)	2.8 (1, 56)	3.5 (2, 79)
TNF-alpha (pg/ml): median (min, max)b
Baseline	1.9 (1, 5)	1.9 (1, 9)	1.8 (1, 7)
24 h	3.8 (1, 9)	3.7 (2, 11)	4.1 (2, 12)
72 h	2.6 (1, 7)	2.2 (0, 12)	3.8 (1, 9)
IFN-gamma (pg/ml): median (min, max)c
Baseline	0.6 (1, 4)	0.6 (1, 4)	0.6 (1, 2)
24 h	75.5 (1, 363)	40.7 (1, 872)	98.2 (4, 3479)
72 h	2.0 (1, 24)	1.6 (1, 12)	3.1 (1, 10)
hs-CRP (mg/l): median (min, max)d
Baseline	2.3 (0, 13)	2.3 (1, 8)	1.8 (0, 49)
24 h	8.0 (0, 81)	4.7 (1, 45)	7.8 (0, 77)
72 h	25.1 (0, 89)	19.3 (1, 133)	20.2 (0, 71)

ACET acetaminophen, FLUV fluvastatin, hs-CRP highly sensitive C-reactive protein, PLAC placebo

^aIL-6 (pg/ml) normal reference range: 0.51–4.92

^bTNF-alpha (pg/ml) normal reference range: less than 1.86

^cIFN-gamma (pg/ml) normal reference range: less than 1.9

^dhs-CRP (mg/l) normal reference range: less than 3.0