Table II.
Conditioning regimens
Regimen | Total dose | Daily dose | Administration | Days | |
---|---|---|---|---|---|
Patient 1 | Flu | 150 mg/m2 | 30 mg/m2 | i.v. in 30 min | −7, −6, −5, −4, −3 |
Mel | 140 mg/m2 | 70 mg/m2 | i.v. in 1 h | −3, −2 | |
Patient 1a | Bu | 20 mg/kg | 5 mg/kg | p.o. q 6 h | −9, −8, −7, −6 |
Cy | 200 mg/kg | 50 mg/kg | i.v. in 1 h | −5, −4, −3, −2 | |
ATGb | 7.5 mg/kg | 3.75 mg/kg | i.v. in 8–10 h | −3, −2 | |
Patient 2 | Bu | 16 mg/kg | 4 mg/kg | p.o. q 6 h | −9, −8, −7, −6 |
Cy | 200 mg/kg | 50 mg/kg | i.v. in 1 h | −5, −4, −3, −2 | |
ATGb | 10 mg/kg | 2.5 mg/kg | i.v. in 8–10 h | −4, −3, −2, −1 | |
Patient 3 | Bu | 20 mg/kg | 5 mg/kg | p.o. q 6 h | −7, −6, −5, −4 |
Cy | 120 mg/kg | 60 mg/kg | i.v. in 1 h | −3, −2 | |
ATGc | 60 mg/kg | 20 mg/kg | i.v. in 8–10 h | −3, −2, −1 | |
Patient 4 | Bu | 20 mg/kg | 5 mg/kg | p.o. q 6 h | −9, −8, −7, −6 |
Cy | 200 mg/kg | 50 mg/kg | i.v. in 1 h | −5, −4, −3, −2 | |
ATGc | 60 mg/kg | 20 mg/kg | i.v. in 8–10 h | −3, −2, −1 | |
Patient 5 | Bu | 20 mg/kg | 5 mg/kg | p.o. q 6 h | −9, −8, −7, −6 |
Cy | 200 mg/kg | 50 mg/kg | i.v. in 1 h | −5, −4, −3, −2 | |
ATGb | 10 mg/kg | 2.5 mg/kg | i.v. in 8–10 h | −3, −2, −1 | |
Patient 6 | Bu | 20 mg/kg | 5 mg/kg | p.o. q 6 h | −9, −8, −7, −6 |
Cy | 200 mg/kg | 50 mg/kg | i.v. in 1 h | −5, −4, −3, −2 |
Flu fludarabine, Mel melphalan, Bu busulphan, Cy cyclophosphamide, ATG rabbit anti-T-cell globulin
aAt second transplantation
bGenzyme
cFresenius