Table 1.

Comparison between two BA receptors in liver.

Receptor	FXR	TGR5
Ligands*	CDCA > LCA, DCA > CA	LCA > DCA > CDCA > CA
Liver cell expression	Hepatocyte, stellate cell, Sinusoid endothelial cell	Sinusoid endothelial cell Kupffer cell, hepatocyte
Functions in liver	BA metabolism, antiapoptosis Anti-inflammatory response, liver regeneration, HCC suppression	Suppress LPS response, glucagon expression, energy metabolism, liver inflammation, and HCC?

*CDCA: chenodeoxycholic acid; CA: cholic acid; DCA: deoxycholic acid; LCA: lithocholic acid; LPS: lipopolysaccharide.