Table 3.
Distribution of TP53/CTNNB1 mutations and clinicopathological data according to HBV infection status.
| Overt HBV infections n = 13* | Occult HBV infections n = 5 | Negative for both HBsAg and HBV DNA n = 5 | Total | |
|---|---|---|---|---|
| TP53 | ||||
| R249S | 5 | 0 | 0 | 5 |
| Other mutation | 1 | 1 | 0 | 2 |
| WT | 7 | 4 | 5 | 16 |
|
| ||||
| CTNNB1 | ||||
| MUT | 3 | 2 | 0 | 5 |
| WT | 7 | 3 | 4 | 14 |
|
| ||||
| HCV | 2 | 1 | 1 | 4 |
|
| ||||
| Sex | ||||
| M | 13 | 4 | 3 | 20 |
| F | 0 | 1 | 2 | 3 |
|
| ||||
| Grade | ||||
| ≥3 | 7 | 2 | 2 | 11 |
| <3 | 6 | 3 | 3 | 12 |
|
| ||||
| HCC morphology | ||||
| Trabecular | 11 | 5 | 2 | 18 |
| Pleiomorphic | 2 | 0 | 1 | 3 |
| Pseudoglandular | 1 | 0 | 1 | 2 |
| Necrosis | 1 | 0 | 2 | 3 |
|
| ||||
| Age | 43.2 ± 12.12 | 51.4 ± 15.2 | 49.4 ± 13.7 | |
WT = wildtype, MUT = mutant, *three HBV-DNA positive cases with missing data on serology were omitted in this table, † CTNNB1 was not amplifiable in four cases, three cases with overt HBV infection and one HBV-negative case.