TABLE 2.
Erythrocyte parameter | Case 1 | Healthy control to case 1 | Case 2 | Healthy control to case 2 |
---|---|---|---|---|
PFK activity* IU/g Hb (%) | 0.78 (11) | 6.8 (100) | 0.78 (12) | 6.5 (100) |
PFK activity† IU/g Hb (%) | — | — | 1.35 (9) | 15.0 (100) |
DPG content mmol/mL RBC (%) | 0.56 (8) | 7.14 (102) | 1.67 (24) | 7.0 (100) |
Hb-O2 dissociation (P50)§ mm Hg | — | — | 19.6 | 28 |
Wachtelhund dogs and healthy controls were studied simultaneously (% of healthy controls).
PFK activity measured at Uppsala University Hospital
PFK activity measured at University of Pennsylvania
P50 refers to the oxygen tension at which 50% of the Hb is bound to oxygen.
DPG, 2,3-diphosphoglycerate; Hb, hemoglobin; Hb-O2, hemoglobin-oxygen; RBC, red blood cell