Table 1.
Parameters by micro-CT analysis of 4th lumbar (L4) and tibia epiphysis
| Parameter | Baseline (14 weeks) | Treatment (29 weeks) | |||
|---|---|---|---|---|---|
| Sham-Walking | Sham-Inactive | OVX-Walking | OVX-Inactive | ||
| BV/TV (%) | |||||
| L4 | 41.3 (1.4) | 27.0 (1.5) | 26.2 (1.5) | 23.8 (1.0)a | 19.6 (1.3)abc |
| Tibia | 22.1 (3.6) | 17.3 (1.2) | 13.8 (1.6)a | 6.0 (0.6)ab | 3.6 (0.4)ab |
| Tb.Th (μm) | |||||
| L4 | 71.4 (2.3) | 69.1 (1.4) | 66.8 (2.1) | 67.5 (1.2) | 64.3 (1.9)abc |
| Tibia | 56.0 (0.7) | 61.0 (1.4) | 55.6 (1.8) | 54.3 (1.8) | 48.6 (1.6)a |
| Tb.N (mm−1) | |||||
| L4 | 5.80 (0.07) | 3.99 (0.15) | 3.93 (0.11) | 3.57 (0.11) | 3.09 (0.1)abc |
| Tibia | 3.87 (0.24) | 2.76 (0.16) | 2.49 (0.23) | 1.14 (0.08)ab | 0.71 (0.07)ab |
| Tb.Sp (μm) | |||||
| L4 | 102.1 (3.2) | 182.2 (10.2) | 187.5 (8.6) | 213.7 (9.1) | 260.7 (15.1)abc |
| Tibia | 204.4 (15.9) | 304.6 (23.4) | 347.2 (48.7) | 828.6 (61.5)ab | 1373.2 (112.8)abc |
Values are the median (SE); n = 6/group. Within the treatment groups, aP < 0.05, versus Sham-Walking; bP < 0.05, versus Sham-Inactive; cP < 0.05, versus OVX-Walking by Bonferroni’s multiple comparison test. Except for the BV/TV (Tibia) and Tb.Th (L4 and Tibia), all values in the Sham-Walking group are significantly different from the Baseline values, P < 0.05