Table 2.
Parameters by pQCT analysis of femur and tibia diaphysis
| Parameter | Baseline (14 weeks) | Treatment (29 weeks) | |||
|---|---|---|---|---|---|
| Sham-Walking | Sham-Inactive | OVX-Walking | OVX-Inactive | ||
| Ct.BMD (mg/cm3) | |||||
| Femur | 1279 (4) | 1367 (5) | 1368 (3) | 1366 (3) | 1375 (3) |
| Tibia | 1235 (3) | 1347 (3) | 1345 (5) | 1355 (5) | 1354 (7) |
| Ct.BMC (mg/mm) | |||||
| Femur | 4.9 (0.1) | 8.3 (0.2) | 7.4 (0.2)a | 8.3 (0.2)b | 7.5 (0.1)ac |
| Tibia | 3.4 (0.1) | 5.6 (0.2) | 5.3 (0.1) | 6.0 (0.1)b | 5.2 (0.1)c |
| Ct.Ar (mm2) | |||||
| Femur | 3.8 (0.1) | 6.1 (0.1) | 5.5 (0.1)a | 6.0 (0.1)b | 5.4 (0.1)ac |
| Tibia | 2.7 (0.1) | 4.2 (0.1) | 3.9 (0.2)a | 4.3 (0.1)b | 3.9 (0.1)c |
| Ct.th (mm) | |||||
| Femur | 0.54 (0.01) | 0.68 (0.01) | 0.66 (0.01) | 0.68 (0.02) | 0.63 (0.01) |
| Tibia | 0.49 (0.01) | 0.68 (0.02) | 0.68 (0.01) | 0.71 (0.02) | 0.64 (0.01) |
| Ma.Ar (mm2) | |||||
| Femur | 2.46 (0.09) | 3.71 (0.20) | 3.06 (0.05)a | 3.57 (0.08)b | 3.45 (0.07) |
| Tibia | 1.35 (0.04) | 1.50 (0.10) | 1.03 (0.03)a | 1.33 (0.08)b | 1.30 (0.04)b |
| Ps-Pm (mm) | |||||
| Femur | 8.9 (0.1) | 11.1 (0.2) | 10.4 (0.1)a | 10.9 (0.1)b | 10.5 (0.1) |
| Tibia | 7.1 (0.1) | 8.3 (0.2) | 7.8 (0.1)a | 8.4 (0.1)b | 8.1 (0.1)c |
| Ec-Pm (mm) | |||||
| Femur | 5.6 (0.1) | 6.8 (0.2) | 6.2 (0.1)a | 6.7 (0.1)b | 6.6 (0.1) |
| Tibia | 4.1 (0.1) | 4.3 (0.2) | 3.6 (0.1)a | 4.1 (0.1)b | 4.1 (0.1) |
| CSMI (mm4) | |||||
| Femur | 3.0 (0.3) | 6.4 (0.4) | 5.1 (0.1)a | 6.1 (0.2) | 5.5 (0.2) |
| Tibia | 1.2 (0.1) | 2.2 (0.2) | 1.4 (0.1)a | 2.0 (0.1)b | 1.7 (0.1) |
Values are the median (SE); n = 6/group. Within the treatment groups, aP < 0.05, versus Sham-Walking; bP < 0.05, versus Sham-Inactive; cP < 0.05, versus OVX-Walking by Bonferroni’s multiple comparison test. All values in the Sham-Walking group except for the tibial Ec-Pm are significantly different from the Baseline values, P < 0.05