Table 2.

In vitro inhibition data of bacterial CAs with sulfonamides and sulfamates, some of which are clinically used drugs (only the enzymes for which these data were reported in the literature are included).

Compound	Ki (μM)
	hpαCA	hpβCA	mtCA 1	mtCA 2	mtCA 3	bsCA 1	bsCA 2	stCA1	stCA2
AAZ	0.021	0.040	0.481	0.009	0.104	0.063	0.303	0.059	0.084
MZA	0.225	0.176	0.781	0.660	0.562	0.054	0.642	0.134	0.068
EZA	0.193	0.033	1.03	0.027	0.594	0.017	0.420	0.528	0.721
DCP	0.378	0.105	0.872	2.01	0.611	0.058	0.112	0.090	0.095
DZA	4.36	0.073	0.744	0.099	0.137	0.021	0.923	0.445	0.607
BRZ	0.210	0.128	0.839	0.127	0.201	0.026	0.625	0.687	0.412
BZA	0.315	0.054	0.810	0.467	0.338	0.075	0.117	0.085	0.098
TPM	0.172	0.032	0.612	0.474	3.02	0.057	0.099	0.624	0.697
ZNS	0.231	0.254	28.68	0.876	0.208	1.85	0.406	5.43	5.70
SLP	0.204	0.035	2.30	0.266	7.92	0.019	0.084	5.64	8.73
IND	0.413	0.143	0.097	0.717	7.84	0.050	0.130	8.86	6.90
CLX	nt	nt	10.35	0.713	7.76	0.018	0.128	5.83	6.11
VLX	nt	nt	12.97	0.682	7.81	0.019	0.612	6.85	6.58

Nt, not tested.